Single Document Publishing fails for a Microsoft PowerPoint file in Vault.
The affected Microsoft PowerPoint file uses the .ppt extension and is not created properly (often due to improper MIME format when the source file is created). Though .ppt files are supported in Single Document Publishing, if they are improperly created, they fail in Vault.
The solution is to convert the affected Microsoft PowerPoint file to a newer version that uses the .pptx extension.
Vault Multichannel Documentation: Using Single Document Multichannel Publishing (Vault PromoMats and Vault Medical)