Is it possible to auto-file Reference Documents into a Compliance Package binder in Vault?
This is not possible in Vault at this time. The Compliance Package generation process takes any document that is included as part of the corresponding bulk action and places it in the Promotional Materials folder regardless of its Document Type.
If the affected Promotional Materials documents have a linked document using a document type equal to what is shown in the screenshot below, those documents are added to the Prescribing Information section.
Vault 2253 Documentation: Generating Form 2253 (PromoMats)
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